Airway branching has conserved needs for local parasympathetic innervation but not neurotransmission
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چکیده
منابع مشابه
Defective parasympathetic innervation is associated with airway branching abnormalities in experimental CDH.
Developmental mechanisms leading to lung hypoplasia in congenital diaphragmatic hernia (CDH) remain poorly defined. Pulmonary innervation is defective in the human disease and in the rodent models of CDH. We hypothesize that defective parasympathetic innervation may contribute to airway branching abnormalities and, therefore, lung hypoplasia, during lung development in CDH. The murine nitrofen ...
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Autonomic nerves distribute by a variety of methods. They are recognized as components of all spinal and some cranial nerves, but they also have a strong tendency to exhibit a hitch-hiker relationship to arteries and to other nerves. The perivascular plexuses of the head and neck, and of the thorax and abdomen, are especially typical of peripheral sympathetic distribution. In the parasympatheti...
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Little is known about the neuronal voltage-gated sodium channels (NaVs) that control neurotransmission in the parasympathetic nervous system. We evaluated the expression of the α subunits of each of the nine NaVs in human, guinea pig, and mouse airway parasympathetic ganglia. We combined this information with a pharmacological analysis of selective NaV blockers on parasympathetic contractions o...
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ژورنال
عنوان ژورنال: BMC Biology
سال: 2014
ISSN: 1741-7007
DOI: 10.1186/s12915-014-0092-2